What is it about?

Structures of upper aerodigestive tract are moderately estrogen dependent; they are endangered by cancer development only in case of deep estrogen deficiency. By contrast, female reproductive organs have high estrogen demand and even a mild defect of estrogen surveillance may be cancer risk factor for them.

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Why is it important?

Cellular estrogen surveillance may be regarded as strong defense against cancer initiation and progression. Cancer prevention and treatment may be performed by exogenous estrogen treatment or by developing new estrogen sensitizing drugs.


Both smoking associated oral cancer and hormone related breast cancer derive from the same genetic defect, namely, deficient estrogen signaling. This recognition supplies great possibilities for cancer treatment.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

Read the Original

This page is a summary of: Common soil of smoking-associated and hormone-related cancers: estrogen deficiency, Oncology Reviews, January 2010, Springer Science + Business Media,
DOI: 10.1007/s12156-010-0036-1.
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