What is it about?

we compared the efficacy of oral paracetamol and oral ibuprofen for the management of acute headache in children with migraine without aura, among 50 children in a randomized-controlled trial at the Pediatric department of a public hospital in India between 20 May, 2017 and 22 March, 2018, and enrolled children,

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Why is it important?

Not much information is available on the relative efficacy of first-line analgesics, paracetamol and ibuprofen in the acute treatment of migraine in children. Both pain-freedom and pain-relief were similar in the Paracetamol and Ibuprofen groups. Ten (23.2%) children had a side-effect due to the study drug, with no significant difference between the groups.


Both of these are easily available cheap drugs, but not much data was available on their relative efficacy for this common problem, migraine in children. Although, we couldn't enroll the required sample size, our data showed no major differences.

Dr Devendra Mishra
Maulana Azad Medical College

Read the Original

This page is a summary of: Paracetamol versus Ibuprofen for the Acute Treatment of Migraine Headache in Children: A Blinded Randomized Controlled Trial, The Indian Journal of Pediatrics, May 2020, Springer Science + Business Media,
DOI: 10.1007/s12098-020-03315-x.
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