What is it about?
60 consecutive infants (1-24 month, 39 males) attending a large public hospital in New Delhi, India were evaluated over a 12-month period to determine the likely etiology and their developmental status. Perinatal asphyxia (45%) and malformations of cortical development (18.3%) were the commonest etiologies. Neurological examination was abnormal in 68.3%, and a neuroimaging abnormality was present in 76%; 15 (25%) had West syndrome. Developmental delay (DQ < 70) was the commonest co-morbidity (81.7%); 28.3% had profound delay. Odds of having developmental delay were 13-times higher in those with an abnormal neurological examination [OR 13.5 (2.82–64.67), P = 0.001], and nearly 9-times higher with abnormal neuroimaging [OR 8.9 (2.11–37.9), P = 0.003].
Featured Image
Why is it important?
No previous information on epilepsy in infants is available from India. Although limited by the small sample size (n=60) and the non-availability of genetic testing, this study provides important information on the etiology of epilepsy in Indian infants.
Perspectives
The high association with developmental delay guided us in prospectively planning for high-risk developmental follow-up of these children.
Dr Devendra Mishra
Maulana Azad Medical College
Read the Original
This page is a summary of: Clinico-etiological Profile and Developmental Status of Infants Aged 1–24 months with Epilepsy, The Indian Journal of Pediatrics, April 2019, Springer Science + Business Media,
DOI: 10.1007/s12098-019-02943-2.
You can read the full text:
Contributors
The following have contributed to this page
