What is it about?

60 consecutive infants (1-24 month, 39 males) attending a large public hospital in New Delhi, India were evaluated over a 12-month period to determine the likely etiology and their developmental status. Perinatal asphyxia (45%) and malformations of cortical development (18.3%) were the commonest etiologies. Neurological examination was abnormal in 68.3%, and a neuroimaging abnormality was present in 76%; 15 (25%) had West syndrome. Developmental delay (DQ < 70) was the commonest co-morbidity (81.7%); 28.3% had profound delay. Odds of having developmental delay were 13-times higher in those with an abnormal neurological examination [OR 13.5 (2.82–64.67), P = 0.001], and nearly 9-times higher with abnormal neuroimaging [OR 8.9 (2.11–37.9), P = 0.003].

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Why is it important?

No previous information on epilepsy in infants is available from India. Although limited by the small sample size (n=60) and the non-availability of genetic testing, this study provides important information on the etiology of epilepsy in Indian infants.


The high association with developmental delay guided us in prospectively planning for high-risk developmental follow-up of these children.

Dr Devendra Mishra
Maulana Azad Medical College

Read the Original

This page is a summary of: Clinico-etiological Profile and Developmental Status of Infants Aged 1–24 months with Epilepsy, The Indian Journal of Pediatrics, April 2019, Springer Science + Business Media,
DOI: 10.1007/s12098-019-02943-2.
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