What is it about?
Boric acid is known to regulate the proliferation of cancer cells. Prostate cancer is among the types of cancer with high mortality in men. There are a few numbers of studies investigating the effects of boric acid on prostate cancer cells. The objective of the thepresent study was to assess the effects of boric acid at concentrations higher than that can be achieved in blood by dietary intake on DU-145 human prostate cancer cells for 24 h. In the current study, we aimed at ascertaining the apoptotic and oxidative effects of different concentrations of boric acid treatment in DU-145 prostate cancer cell line in detail.
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Why is it important?
Boron, a trace element for organisms, has a high affinity for oxygen and is found abundant in nature as borate forms, such as boric acid and borax [1, 2]. Boric acid, a soluble form of boron, is rapidly absorbed from the gastrointestinal tract following dietary intake, passes to the blood flow, and is involved in many physiological and biochemical processes through its antioxidant or anticancer properties
Perspectives
Boric acid, although its IC50 is high, has the potential to be used as an adjuvant with common chemoterapic agents. Our findings give important insights about boric acid dose and its effect on prostate cells for future studies.
Sedat Kacar
Eskisehir Osmangazi Universitesi
Read the Original
This page is a summary of: High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line, Biological Trace Element Research, May 2019, Springer Science + Business Media,
DOI: 10.1007/s12011-019-01739-x.
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