What is it about?
Factor V Leiden (FVL) mutation is the most common genetic risk factor for venous thromboembolism. In families with a history of thrombosis, FVL can be present in 18%. Thrombin generation test is commonly used as an evaluation tool of thrombotic risk. The objective of this study was to evaluate the thrombogenic potential of FVL in asymptomatic carriers, in patients with personal or familial history of thrombosis.
Featured Image
Why is it important?
With thrombin generation assay, we can predict idiopathic thrombosis development in asymptomatic carriers. Moreover, patients who developped an idiopathic pulmonary embolism have a higher basal hypercoagulable states
Perspectives
The results of our analysis suggest that measurement of thrombin generation in patients with FVL mutation may identify subjects with an increased risk of unprovoked thrombosis. Further studies are needed to examine the usefulness of predicting thrombotic presentation in asymptomatic carriers.
Paul Billoir
Rouen University Hospital Vascular Hemostasis Unit
Read the Original
This page is a summary of: Thrombin generation profile in non-thrombotic factor V Leiden carriers, Journal of Thrombosis and Thrombolysis, January 2019, Springer Science + Business Media,
DOI: 10.1007/s11239-019-01821-0.
You can read the full text:
Contributors
The following have contributed to this page
