What is it about?
We performed a family extensive literature review over a couple of years to summarize the various articles describing HTS or computational repurposing for neglected diseases. We also collect these various active compounds and summarize their drug-likeness.
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Why is it important?
It goes beyond the various pathogen / malaria box screens that have been widely published. It also summarizes the neglected diseases that can obtain a neglected disease priority review voucher from the FDA. We summarize several molecules that show activity against multiple neglected diseases.
Perspectives
Helen did much of the initial literature analysis and this was bolstered with text from the rest of the team that summarized their various areas of expertise. The review may serve as a starting point for anyone starting to work on any of these diseases.
Dr Sean Ekins
Collaborations in Chemistry
Read the Original
This page is a summary of: High Throughput and Computational Repurposing for Neglected Diseases, Pharmaceutical Research, December 2018, Springer Science + Business Media,
DOI: 10.1007/s11095-018-2558-3.
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