What is it about?
This paper describes using 3 dose response and cytotoxicity bayesian models for TB to predict 1924 additional molecules. This represents external testing on a pretty big scale.
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Why is it important?
We sho the value of these models for predicting compounds from our lab and from the literature. We generally see >10 fold enrichment.
Read the Original
This page is a summary of: Combining Computational Methods for Hit to Lead Optimization in Mycobacterium Tuberculosis Drug Discovery, Pharmaceutical Research, October 2013, Springer Science + Business Media,
DOI: 10.1007/s11095-013-1172-7.
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