TB whole cell models for aerobic activity
What is it about?
We used a small TB whole cell data set published by Novartis (aerobic and anaerobic hits) as a test set for previously published Bayesian models. We demonstrated enrichment over random screening. We also used a published dataset of FDA approved drugs as a test set.
Why is it important?
This represents one of the early validation studies for the bayesian models which we built with public TB datasets. We also built a model with this small dataset to identify aerobic hits.
The following have contributed to this page: Dr Sean Ekins and Joel Freundlich