What is it about?
We have shown that both oxidative stress and inflammation may be involved in inducing neurodegeneration in thiamine deficiency. We also show the involvement of important cellular mechanisms in the process.
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Why is it important?
Very little is yet known about the cellular mechanisms of thiamine deficiency-induced neurodegeneration. In this study, we show the involvement of the p38MAPK pathway and HO-1 modulation in the thalamus of deficient mice.
Perspectives
With these results, new perspectives for a therapeutic approach are created for diseases associated with thiamine deficiency.
Dr Fabiano Mendes de Cordova
Universidade Federal do Norte do Tocantins
Read the Original
This page is a summary of: Thiamine Deficiency Modulates p38MAPK and Heme Oxygenase-1 in Mouse Brain: Association with Early Tissue and Behavioral Changes, Neurochemical Research, January 2020, Springer Science + Business Media,
DOI: 10.1007/s11064-020-02975-7.
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