What is it about?
We demonstrate that neural progenitor-like cells generated from bone marrow mesenchymal stem cells are not able to proliferate as neurospheres, and they do not differentiate into mature neurons. We performed a small molecule screen and found a chemical cocktail able to convert mesenchymal stem cells directly into mature neurons.
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Why is it important?
This findings have important implications to generate neurons directly from mesenchymal stem cells for neural replacement therapies, without passing through a neural progenitor stage.
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This page is a summary of: Improved Proliferative Capacity of NP-Like Cells Derived from Human Mesenchymal Stromal Cells and Neuronal Transdifferentiation by Small Molecules, Neurochemical Research, November 2016, Springer Science + Business Media,
DOI: 10.1007/s11064-016-2086-7.
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail
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Improved Proliferative Capacity of NP-Like Cells Derived from Human Mesenchymal Stromal Cells and Neuronal Transdifferentiation by Small Molecules
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