What is it about?

It is plausible that multiple muscle biopsies following a muscle damaging intervention can exacerbate the inflammatory and subsequent satellite cell responses. To elucidate confounding effects of muscle biopsy procedure on satellite cell number, indirect markers of damage and the inflammatory response following acute downhill running (DHR) were investigated.

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Why is it important?

Since no significant changes over time were observed in the control group for any of the variables measured, it can be concluded that the events observed in the DHR group were as a consequence of the intervention protocol and subsequent muscle damage. This finding is important because it allows for future experimentation on the integration between the nature of muscle damage, the inflammatory response and the subsequent satellite cell proliferation to be investigated with doubt that the findings could be assigned to a biopsy response. This is also the first study to show that a relatively simple whole body exercise such as DHR is sufficient to induce a similar extent of SC proliferation compared with more extreme eccentric exercise of isolated muscle groups. The relationship between SC proliferation and pro-inflammatory cytokine release appears to be complex since the IL-6/IL-10 response time differs significantly from the TNF-a response.

Perspectives

This publication opened the door for future experimentation on the integration between the nature of tissue damage, the inflammatory response and the subsequent progenitor cell proliferation to be investigated without doubt that the findings could be assigned to a biopsy response.

Dr Mari van de Vyver
Stellenbosch University

Read the Original

This page is a summary of: Cytokine and satellite cell responses to muscle damage: interpretation and possible confounding factors in human studies, Journal of Muscle Research and Cell Motility, June 2012, Springer Science + Business Media,
DOI: 10.1007/s10974-012-9303-z.
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