What is it about?
The objective in the design of a radiopharmaceutical is to maximize the amount that gets to the target and to minimize non-target accumulation. Prelabeling is one strategy to increase that objective. We add the radioisotope to the targeting molecule in order to maximize the yield and deliver more of the injected activity to the target.
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Why is it important?
The aim of molecular imaging is to gain understanding of the patient's condition and minimizing the impact on the patient. By prelabeling, we are ensuring that the radioactivity that is injected is active and will seek the target. We do not want un-reacted radioactivity to be injected as it will increase the radiation dose to the patient without gaining any additional information.
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This page is a summary of: Development of a prelabeling approach for a targeted nanochelator, Journal of Radioanalytical and Nuclear Chemistry, February 2015, Springer Science + Business Media,
DOI: 10.1007/s10967-015-3976-x.
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