Granulocyte‑colony stimulating factor ameliorates DEHP‑induced cardiac muscle injury

What is it about?

Phthalates are common plasticizers present in medical-grade plastics and other everyday products. Di-ethylhexyl phthalate (DEHP) has been noted as a causative risk factor for the initiation and augmentation of cardiovascular functional disorders. G-CSF is a glycoprotein found in numerous tissues throughout the body and is currently applied in clinical practice

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Why is it important?

In conclusion, our results endorse our assumption that G-CSF has a propitious protective effect in correcting the DEHP-induced cardiac alterations, both by its effect on cardiomyocytes and by recruiting stem cells from bone marrow. We proved the ameliorative effect of G-CSF was through regulation of cardiac Desmin protein levels in addition to inhibitory effect on cardiac muscle fibrosis and apoptosis. With no recorded adverse effects of G-CSF at the levels utilized in this trial, our findings indicate that treatment with G-CSF may be regarded as a potentially novel option for the treatment of DEHP-induced cardiotoxicity.