Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthroline-trithiacyclononane

  • Joana Marques, Teresa M. Braga, Filipe A. Almeida Paz, Teresa M. Santos, Maria de Fátima Silva Lopes, Susana S. Braga
  • BioMetals, February 2009, Springer Science + Business Media
  • DOI: 10.1007/s10534-009-9211-x

What is it about?

Cyclodextrins are used to help solubilise many drugs. In this work we investigated whether they also help improve the efficacy of anti-bacterial compounds. For this, we tested a new metal agent against various bacteria both in the pure form and when combined with cyclodextrins. Results varied from one strain to another, but as a big picture it can be concluded that the cyclodextrin named TRIMEB helps improve of antibacterial action of the metal agent against pathogenic strains while making it less aggressive for environmental, non-pathogenic strains.

Why is it important?

This paper shows a new strategy for making antimicrobial agents more environmental friendly.

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http://dx.doi.org/10.1007/s10534-009-9211-x

The following have contributed to this page: Dr Susana Santos Braga

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