What is it about?
In this study, we developed a co-culture model with brain and vascular cells which resembles the in vivo neurovascular niche and mimics the intricate interactions between the these populations. We also demonstrated that vascular cells are able to protect brain cells by release of specific neurotrophic factors.
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Why is it important?
In summary, our data demonstrate that vascular cells are resistant to toxicity induced by neurotoxin in vitro and grant protection against cytotoxic signals in brain cells probably through stimulation of endogenous survival signaling pathways. These results on protective pathways could be transformed in therapeutic targets even in Parkinson's disease patients
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This page is a summary of: Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson’s disease, APOPTOSIS, December 2011, Springer Science + Business Media,
DOI: 10.1007/s10495-011-0679-9.
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