A mouse model of chronic bacterial lesions (a cotton trap) for studying oral bacteria - lymphocyte interactions

What is it about?

We established a mouse model of chronic bacterial infection (cotton trap) to get a deeper insight into interactions between immune cells and bacterial strains, that are most commonly isolated from periapical processes.

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Why is it important?

We provide evidence that anaerobic bacteria (Bacteroides sp.) and nocardiae are more effective in inducing cytotoxic immunity and Th1 response compared to oral streptococci.