What is it about?
SUMO is a small ubiquitin-like protein modifier that is covalently attached to other proteins. It can alter protein localisation, protein-protein interactions and protein activity. It thus has important regulatory roles within cells. This review summarises what is know about how the process of sumoylation is regulated, in terms of both conjugation and deconjugation.
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Why is it important?
Sumoylation is an important post-translational modification. It affects many cellular process, thus understanding how it is regulated will provide important insights into many aspects of cell regulation
Read the Original
This page is a summary of: Starting and stopping SUMOylation, Chromosoma, June 2013, Springer Science + Business Media,
DOI: 10.1007/s00412-013-0422-0.
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Resources
Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance
This describes out identification of the SUMO activating enzyme from fission yeast
Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation
This describes out analysis of the effect of mutation in the SUMO conjugating enzyme
SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52
This describes the establishment and use of an in vitro sumoylation assay from fission yeast
SUMO modification of proteins other than transcription factors
Role of sumoylation of proteins other then transcription factors.
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