What is it about?
The purpose of this study was to evaluate the cardiac and cerebral oxidative stress in the offspings of pregnant rats treated with oxytocin antagonist atosiban.
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Why is it important?
Oxytocin receptor blockage for the treatment of premature delivery may be associated with increased fetal morbidity and mortality secondary to the elevated oxidative stress in the heart of the newborns.
Perspectives
According to the best of our knowledge, this is the Wrst time such an observation has been reported in an experimental model. For mentioned reasons above, to prevent the possible deleterious eVects of the atosiban associated-oxidative stress in the newborns, the addition of antioxidant therapy may be considered in women with a diagnosis of premature delivery, and treated with oxytocin antagonists.
Dr Sedat Bilgiç
Adiyaman Universitesi
Read the Original
This page is a summary of: Elevated cardiac oxidative stress in newborn rats from mothers treated with atosiban, Archives of Gynecology and Obstetrics, August 2011, Springer Science + Business Media,
DOI: 10.1007/s00404-011-2069-5.
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