What is it about?
Intravenous Amphotericin B is used in the treatment of deep Mycoses. However,complications from its use is common, often toxic, interrupts treatment and sometimes fatal. The study tested the efficacy of safer oral Fluconazole in treating multiple osteomyelitis caused by disseminated African Histoplasmosis.
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Why is it important?
Effective and safe alternative drug to Amphotericin B will eliminate the problems of toxicity from drugs when treating these types of patients.
Perspectives
Even though the sample size is small, the remarkable good result is noteworthy. The result informs a larger trial of oral Fluconazole in the treatment of multiple osteomyelitis from disseminated African histoplasmosis.
Professor Okechukwu Onwuasoigwe
University of Nigeria
Read the Original
This page is a summary of: Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis, International Orthopaedics, June 1999, Springer Science + Business Media,
DOI: 10.1007/s002640050312.
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