High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury

What is it about?

What is known about this subject? • Lung-transplant recipients often develop acute kidney injury evolving into chronic kidney disease increasing both morbidity and mortality • To date, the pathophysiology of acute kidney injury after lung transplantation has not been fully elucidated • The immunosuppressant tacrolimus, which is nephrotoxic, is difficult to dose in the unstable clinical setting What this study adds: • Supra-therapeutic whole-blood tacrolimus trough concentrations are related to the emergence of acute kidney injury in the first days after lung transplantation • Supra-therapeutic whole-blood tacrolimus trough concentrations often occur early after lung transplantation • AKI after lung transplantation shows low recovery rates and often evolves to severe chronic kidney

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