What is it about?

This publication explores the relationship of a set of genotypes of drug metabolizing enzymes to plasma clearance as well as most common adverse effect of a commonly used cytotoxic and immunosuppressive drug cyclophosphamide. It supports involvement of CYP2C19, ALDH3A1 and GSTA1 in this regard.

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Why is it important?

This article explores the genetic basis of variation in breast cancer treatment.

Perspectives

It is an important study to understand the behavior of a commonly used drug to treat breast cancer.

Dr Nasir Ali Afsar
Jinnah Medical & Dental College Karachi; Alfaisal University Riyadh.

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This page is a summary of: Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients, European Journal of Clinical Pharmacology, October 2011, Springer Science + Business Media,
DOI: 10.1007/s00228-011-1134-0.
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