Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles

Ali Athab Al-Kinani, Declan P. Naughton, Gianpiero Calabrese, Anil Vangala, James R. Smith, Barbara K. Pierscionek, Raid G. Alany
  • Analytical and Bioanalytical Chemistry, February 2015, Springer Science + Business Media
  • DOI: 10.1007/s00216-015-8494-8

Drug delivery to the eye for the treatment of cataracts

Photo by Matt on Unsplash

Photo by Matt on Unsplash

What is it about?

Oxidative damage due to low levels of glutathione (GSH) is one of the main causes of cataract formation. A cysteine prodrug, 2-oxothiazolidine-4-carboxylic acid (OTZ), can increase the cellular level of GSH. We have developed a method for determining OTZ content and have used this to determine the loading of nanoparticles containing this drug.

Why is it important?

The paper is a stepping stone to developing therapeutic strategies for treating or preventing cataracts.


Dr James R Smith
University of Portsmouth

A free post-print version is available in the resources section.

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The following have contributed to this page: Dr James R Smith