What is it about?
This study shows that the CoQ0 treatment triggered permeability transition pores (PTP) and led to mitochondrial apoptosis in HL-60 cells. Evidence shows that CoQ0 increased the production of intracellular Reactive Oxygen Species (ROS) in HL-60 cells which might act as upstream signalling molecules to initiate the apoptosis
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Why is it important?
CoQ0 and its analogs have been reported as potential anti-inflammatory, antioxidant and anticancer substances. This finding provides another evidence that, specifically CoQ0, is a promising anticancer agent for the treatment of human leukemia
Perspectives
There are studies reported before using different CoQ analogs that showed increased apoptosis. CoQ0, the novel analog without isoprenoid side chains, has been reported to exert anticancer properties against human breast/lung cancer cells. This study provides more evidences on the anticancer properties of CoQ0, a key ingredient in Antrodia camphorata, a unique mushroom of Taiwan
Dr. You-cheng Hseu
China Medical University
Read the Original
This page is a summary of: CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice, Archives of Toxicology, September 2017, Springer Science + Business Media,
DOI: 10.1007/s00204-017-2050-6.
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