What is it about?
With a saturated genetic map, the confidence interval for location of a segregating QTL becomes a function of the experimental design, the QTL effect, and number of individuals genotyped. We present simple formula to calculate the confidence intervals for most important experimental designs
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Why is it important?
Contrary to accepted opinion at the time, increasing marker density helps only up to a point. Once marker "staturation" has been achieved, the limited factors for determination of confidence interal is the number of recombination events in the sample and the effect of the segregating effect.
Perspectives
I really enjoyed solving this problem
Dr Joel Ira Weller
ARO, The Volcani Center
Read the Original
This page is a summary of: An analytical formula to estimate confidence interval of QTL location with a saturated genetic map as a function of experimental design, Theoretical and Applied Genetics, September 2004, Springer Science + Business Media,
DOI: 10.1007/s00122-004-1664-2.
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