Selecting a suitable pharmacophore for plk-1

What is it about?

This study discusses in detail about the strategies adopted for identification of a suitable pharmacophore that can be used for virtual screening of inhibitors for plk-1. This strategy involves using 3D-QSAR validation and DUD set validation as first and second check-points for the suitability of the pharmacophore.

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Why is it important?

plk-1 is an emerging cell-cycle kinase and extensive research is being carried out for identifying inhibitors. A validated pharmacophore can be a good starting point in the virtual screening for the discovery of new inhibitors.