What is it about?
The alpha subunits of trimeric G proteins fall into five classes, but no function was known for the latest discovered Gv proteins. We have performed a thorough investigation of the expression patten of Gv during zebrafish development to obtain suggestions for possible functions. Furthermore we report reduced oviposition, accelerated hatching, and bone and cartilage dysplasia in a knockout of Gv in zebrafish. Expression of several ion transporters is modified in the mutant fish.
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Why is it important?
This is the first description of a function for Gv, an ancient class of G alpha proteins.
Perspectives
A much needed step to elucidate the function and importance of Gv, 15 years after the discovery of this class of G alpha proteins.
Dr. Sigrun I. Korsching
University of Cologne
Read the Original
This page is a summary of: Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis, Cellular and Molecular Life Sciences, May 2024, Springer Science + Business Media,
DOI: 10.1007/s00018-024-05228-w.
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