What is it about?
The selective 5-HT2 receptor antagonist pirenperone attenuated both morphine analgesia and analgesia produces by electrical stimulation of the nucleus raphe magnus or periaqueductal gray, two sources of the descending inhibition of the spinal cord.
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Why is it important?
This was the first report that distinguished the involvement of serotonin type-2 receptors in the effect of opioid analgesics and analgesia produced by activating the descending inhibitory system that is mediated by opioid interneurons in the spinal cord.
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This page is a summary of: Selective effects of pirenperone on analgesia produced by morphine or electrical stimulation at sites in the nucleus raphe magnus and periaqueductal gray, Psychopharmacology, January 1986, Springer Science + Business Media,
DOI: 10.1007/bf00652235.
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