What is it about?
Brain aging is a complex, multifactorial process marked by gradual cognitive decline, synaptic dysfunction, oxidative stress, and neuroinflammation. In recent years, antiaging compounds—ranging from natural bioactives to synthetic drugs—have shown promising neuroprotective effects that may mitigate or delay these age-related changes. Compounds such as resveratrol, curcumin, metformin, rapamycin, and NAD⁺ precursors (like nicotinamide riboside) target key aging-related pathways, including sirtuins, mTOR signaling, mitochondrial function, and inflammatory cascades. These interventions may preserve neuronal integrity, enhance cognitive performance, and reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This review explores the mechanisms, efficacy, and translational potential of various antiaging agents in promoting healthy brain aging.
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Why is it important?
Antiaging compounds help counteract cognitive decline and neurodegeneration by targeting key aging pathways. Offers a foundation for developing preventive and therapeutic approaches for age-related brain disorders. Encourages biomarker-driven, individualized strategies for brain health in aging individuals.
Perspectives
The potential of antiaging compounds to improve brain health is a rapidly expanding area of interest within neuroscience and gerontology. These agents exert multifaceted effects: boosting mitochondrial efficiency, suppressing chronic inflammation, enhancing autophagy, and supporting neurogenesis. Preclinical studies have demonstrated cognitive enhancement and delayed neurodegeneration, while early-phase clinical trials offer cautious optimism. However, translating these findings into routine clinical practice faces hurdles including variability in bioavailability, long-term safety, and individual genetic and metabolic responses. Personalized antiaging strategies, informed by biomarkers and systems biology, may soon pave the way for targeted interventions aimed at preserving cognitive function and extending healthspan in aging populations.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Potential Effects of Antiaging Compounds: Implications on Brain Aging, January 2024, Springer Science + Business Media,
DOI: 10.1007/978-981-99-7269-2_9.
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