Overview of Diagnosis

What is it about?

Patients with pemphigus vulgaris (PV) are seen to initially suffer from oral erosions and then successively develop cutaneous involvement. Mucous membrane erosions precede cutaneous expressions of the disease and often result in a lengthened course of misdiagnosis with illnesses such as aphthous ulceration. As seen in some cases of PV, painful oral ulceration may appear to be the only indicator of the disease. Common mucosal surfaces that are involved in the manifestation of the disease include the gingiva, soft and hard palate, floor of the mouth, tongue, esophagus, oropharynx, nasal, larynx, urethra, vulva, and cervix. Conjunctiva involvement is less frequently observed in PV. PV patients also demonstrate dysphagia accompanied with weight loss.

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