Introduction and History

What is it about?

Mycosis fungoides (MF) is the most common form of skin lymphoma originating from primary cutaneous T-cell lymphomas (CTCL). MF primarily develops in the skin, but can also involve lymph nodes, blood, and other organs.

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Why is it important?

Patients with MF typically have a prolonged clinical course. Early lesions of MF may show variable degrees of epidermal atrophy, telangiectasia, and/or mottled hyper- or hypopigmentation. In the earliest stages, patients can have nonspecific dermatitis and/or psoriasiform skin lesions for many years. For these reasons and more, diagnosing early MF proves to be challenging.