What is it about?
Results from many laboratories suggest that stem cell niche is comprised by extracellular matrix components such as glycosaminoglycans (GAG's), as well as by different cell types and cell-produced molecules that establish a micro environment, is essential to maintain stem cells`proliferative and differentiation abilities. In this chapter, those elements that seem contribute to establish the niche in which corneal stem cells reside, are described. It is also attempted to link such characteristics with the predicted properties of this cell population.
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Why is it important?
I think that this chapter is important because we tried to integrate all described information regarding corneal stem cell populations in different mammalian species and to show that many different factors lead to compose an specialized environment which is crucial for stem cells maintenance.
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This page is a summary of: The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix, January 2015, Springer Science + Business Media,
DOI: 10.1007/978-3-319-21702-4_2.
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