Ligand- and Structure-Based Pregnane X Receptor Models

  • Sandhya Kortagere, Matthew D. Krasowski, Sean Ekins
  • January 2012, Springer Science + Business Media
  • DOI: 10.1007/978-1-62703-050-2_15

PXR models

What is it about?

A chapter that reviews the knowledge up to 2012 on human Pregnane X Receptor ligand and protein based models.

Why is it important?

It brings together docking and ligand based approaches as methods to predict a molecules interaction with PXR. It predominantly focuses on agonists although it does include discussion of modeling for antagonists.

Perspectives

Dr Sean Ekins
Collaborations in Chemistry

The chapter includes useful advice for avoiding PXR. I have been involved in writing several papers on PXR with both Sandhya and Matt so this brought together our ideas.

Read Publication

http://dx.doi.org/10.1007/978-1-62703-050-2_15

The following have contributed to this page: Dr Sean Ekins