Applications of AFM in Pharmaceutical Sciences

Dimitrios A. Lamprou, James R. Smith
  • January 2016, Springer Science + Business Media
  • DOI: 10.1007/978-1-4939-4029-5_20

Importance of atomic force microscopy in pharmaceutical sciences

What is it about?

Atomic force microscopy (AFM) uses a small tip to move across surfaces of samples to make an image. The tip can also be pushed in or pulled away from a surface to obtain information on stiffness or stickiness (adhesion). This book chapter describes how AFM works in detail and then focuses on how AFM has been used in pharmaceutical research. Areas include tablet coating and dissolution, crystal growth and polymorphism, particles and fibres, nanomedicine, nanotoxicology, drug-protein and protein-protein interactions, live cells, bacterial biofilms and viruses. The selected studies are from 2011 to 2014, both from the literature and a few selected studies from the authors’ laboratories.

Why is it important?

An awareness of how atomic force microscopy is important since the technique is not familiar to many people. The technique can offer many insights to those engaged in the pharmaceutical sciences.

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The following have contributed to this page: Dr James R Smith and Dimitrios A. Lamprou