What is it about?
Surface modification of liposomes with a ligand is facilitated by the conjugation of the ligand to a hydrophobic molecule that serves to anchor the ligand to the liposomal bilayer. We describe here a simple protocol to conjugate a triphenylphosphonium group to several commercially available functionalized phospholipids. The resulting triphenylphosphonium conjugated lipids can be used to prepare liposomes that preferentially associate with mitochondria when exposed to live mammalian cells in culture.
Featured Image
Read the Original
This page is a summary of: Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes, January 2015, Springer Science + Business Media,
DOI: 10.1007/978-1-4939-2288-8_4.
You can read the full text:
Contributors
The following have contributed to this page