What is it about?
Tight junctions are formed by strands that surrounds the whole cell perimeter, seal the extracelular space and confer to the epithelia the capacity to form a selective barrier. Often, these strands anastomose. Here we review the relationship between strands structure and the function of tight junctions: the more complex the structure of the strands, the lower the paracelular permeability.
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Why is it important?
Besides a review general aspects of the tight junctions, we present a model that relates the degree of tight junctions’ filaments interlacing with tight junctions’ permeability.
Perspectives
Simple mathematical models are usefull
Dr Rubén G. Contreras
Cinvestav
Read the Original
This page is a summary of: The Paracellular Pathway, January 1993, Springer Science + Business Media,
DOI: 10.1007/978-1-4615-2898-2_1.
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