What is it about?

The use of NSAIDs is connected to gastro-enteric side effects. In general, their presence is neglected because there are more prevalent damages on the gastro-duodenal tract. The microbiota may influence the incidence of the enteropathy. This article describes in detail what the literature reports on this topic.

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Why is it important?

One of the reason to abandon the NSAID therapy may be the incidence of enteropathy due to these medicines. This review article focus on the reasons for the side effect and suggests some possible remedies.


A deep study of the of the pathophysiological origin of the intestinal lesions due to the use of NSAIDs helps in finding the solution to the problem. It seems that the presence of microbiota in the intestine, and the use of specific probiotics might help.

Professor Giustino Varrassi
Paolo Procacci Foundation

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This page is a summary of: Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics, Advances in Therapy, April 2020, Springer Science + Business Media,
DOI: 10.1007/s12325-020-01338-6.
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