What is it about?

Fractal geometry is a relatively young and promesing mathematical concept. The focus of this article lies on using this powerful tool for monitoring and forecasting the water solubility of dihydroquercetin cocrystals.

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Why is it important?

According to the principles of GMP, a pharmaceutical process must be designed and carried out in such a way that the product quality is analyzed at the end of the process and suitable systems are used for designing, monitoring, and controlling a process with the goal of ensuring final product quality. The fractal model can find wide application in the pharmaceutical industry as a tool for automating quality assays without substance loss.


The preparation of this article was a kind of challenge. I was just a student and was preparing my master thesis. The understanding of the correlation between solubility and fractality of cocrystals was fantastic and seems like a "voodoo". My German scientific supervisor did not think, that the results had been promising for the pharmaceutical industry. However this article is published and I am very thankful to everybody, who make this paper is possible.

Roman P. Terekhov
Sechenov First Moscow State Medical University

Read the Original

This page is a summary of: Fractal Aggregation of Dihydroquercetin After Lyophilization, Journal of Pharmaceutical Innovation, May 2018, Springer Science + Business Media,
DOI: 10.1007/s12247-018-9322-4.
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