Three-Factor Versus Four-Factor Prothrombin Complex Concentrate for the Emergent Management of Warfarin-Associated Intracranial Hemorrhage

  • Daniel Fischer, Jeffrey Sorensen, Gabriel V. Fontaine
  • Neurocritical Care, June 2017, Springer Science + Business Media
  • DOI: 10.1007/s12028-017-0374-y

3- vs 4-factor PCC for Warfarin ICH Reversal

What is it about?

Four-factor prothrombin complex concentrates (PCC) produce a more rapid and complete INR correction compared with 3-factor PCC in patients receiving warfarin. It is unknown if this improves clinical outcomes in the setting of intracranial hemorrhage (ICH). In our study, in-hospital mortality was not improved with the use of 4- versus 3-factor PCC in the emergent reversal of warfarin-associated ICH. Secondary clinical outcomes were similarly nonsignificant.

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The following have contributed to this page: Gabriel V Fontaine