What is it about?

We highlight recent research that shows how physiologic interventions (exercise, dietary etc) begin to reveal the purpose of fat within bone (marrow fat) and how this relates to disorders like osteoporosis.

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Why is it important?

Understanding the function of bone fat in these settings will aid to uncover future pharmacologic and non-pharmacologic therapies for bone disorders such as osteoporosis.


When we encounter obstacles, eg biological processes that are difficult to measure, we are called upon to engage other experts to develop new or improved methodologies which facilitate discoveries in our field. Initial queries more than ten years ago by our lab and others, about the physiologic significance of marrow adipose tissue and how exercise regulates bone, resulted in foundational work that is highlighted in this review.

Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology

Read the Original

This page is a summary of: Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue, Current Osteoporosis Reports, October 2020, Springer Science + Business Media, DOI: 10.1007/s11914-020-00634-y.
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