What is it about?
Colorectal cancer (CRC) is the third most common malignant tumor and has become a major cause of cancer mortality. According to studies conducted recently; carbonic anhydrase 9 (CAIX) is a particularly attractive target for cancer therapy, in part because it is limited as expressed in normal tissues on the other hand in a variety of solid neoplasms are overexpressed.
Photo by National Cancer Institute on Unsplash
Why is it important?
Despite new methods and drugs to treat colorectal cancer and the good results obtained with them, we still have not scratched the surface of therapeutic anticancer drugs, and there is a wide range of chemicals and natural products that have not yet been studied and tested as anticancer agents. - The sulfonamide derivative (H-4i) is considered a new compound with great anti-cancer potential. - For the first time, the apoptotic, cytotoxic and genotoxic properties of the sulfonamide derivative (H-4i) were investigated in different cell lines at different concentrations. - The original study was performed using a standard assay. Apoptosis and cell cycle induction were measured by flow cytometric analysis, and intracellular free radical induction was performed by reactive oxygen species (ROS) analyses.
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This page is a summary of: The cytotoxic, apoptotic and oxidative effects of carbonic anhydrase IX inhibitor on colorectal cancer cells, Journal of Bioenergetics and Biomembranes, March 2018, Springer Science + Business Media, DOI: 10.1007/s10863-018-9749-9.
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