What is it about?
Panax ginseng component panaxydol induces apoptosis, a form of cell death, in cancer cells. A series of intracellular events that is initiated by panaxydol to induce cell death is eludicated, i.e. an increase in intracellular calcium, activation of MAP kinases (JNK and p38), and oxidative stress caused by activation of NADPH oxidase.
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Why is it important?
Panax ginseng panaxydol can kill cancer cells preferentially to nontransformed cells. Understanding how panaxydol can kill cancer cells is important to utilize it as an anti-cancer agent.
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This page is a summary of: Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species, APOPTOSIS, December 2010, Springer Science + Business Media,
DOI: 10.1007/s10495-010-0567-8.
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