What is it about?

A growing body of evidence indicate a co-occurring relationship between endometriosis and depression. However, there is no clear understanding of the relationship nor the potential mechanisms of the association. The present study comprehensively assessed the relationship between endometriosis and depression using genetic study approach. Findings confirmed the comorbidity of endometriosis and depression and suggest the likely role of gastric mucosa disorders (gastritis, duodenitis, peptic ulcer, and gastroesophageal reflux disease) in the causal pathways of the two disorders

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Why is it important?

The study identified genetic factors shared by both endometriosis and depression including SNPs, loci and genes. These are potential targets for therapeutic development in endometriosis and depression. Also, potential biological pathways underlying the two disorders were identified thereby improving our knowledge of the biological mechanisms of endometriosis and depression.

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This page is a summary of: Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality, Human Genetics, September 2020, Springer Science + Business Media,
DOI: 10.1007/s00439-020-02223-6.
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