What is it about?

This population-based study demonstrates two distinct and common Lewy-related pathology (LRP) progression patterns in the brain of very elderly population (85 years and older). There are hierarchical caudo-rostral progression pattern and the amygdala-based pattern. The amygdala-based progression pattern was associated with APOE ε4 and Alzheimer's disease (AD) pathology.

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Why is it important?

The results confirm the previous progression hypotheses but also widen the concept of the AD-associated LRP.


I hope this article helps in understanding of Lewy-related pathology progression behind Lewy body dementia (DLB). When LRP has two different progression patterns and only the amygdala pattern is associated with AD, it is easy to understand the variation of clinical symptoms of DLB. Hopefully one day it will be possible to take this into account in the treatment of DLB.

Minna Oinas
Helsingin Yliopisto

Read the Original

This page is a summary of: Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85+, Acta Neuropathologica, September 2019, Springer Science + Business Media, DOI: 10.1007/s00401-019-02071-3.
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