What is it about?
This population-based study demonstrates two distinct and common Lewy-related pathology (LRP) progression patterns in the brain of very elderly population (85 years and older). There are hierarchical caudo-rostral progression pattern and the amygdala-based pattern. The amygdala-based progression pattern was associated with APOE ε4 and Alzheimer's disease (AD) pathology.
Photo by Robina Weermeijer on Unsplash
Why is it important?
The results confirm the previous progression hypotheses but also widen the concept of the AD-associated LRP.
Read the Original
This page is a summary of: Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85+, Acta Neuropathologica, September 2019, Springer Science + Business Media, DOI: 10.1007/s00401-019-02071-3.
You can read the full text:
The following have contributed to this page