What is it about?

Oxidative damage due to low levels of glutathione (GSH) is one of the main causes of cataract formation. A cysteine prodrug, 2-oxothiazolidine-4-carboxylic acid (OTZ), can increase the cellular level of GSH. We have developed a method for determining OTZ content and have used this to determine the loading of nanoparticles containing this drug.

Featured Image

Why is it important?

The paper is a stepping stone to developing therapeutic strategies for treating or preventing cataracts.


A free post-print version is available in the resources section.

Dr James R Smith
University of Portsmouth

Read the Original

This page is a summary of: Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles, Analytical and Bioanalytical Chemistry, February 2015, Springer Science + Business Media,
DOI: 10.1007/s00216-015-8494-8.
You can read the full text:




The following have contributed to this page