Clinical Research Introduction

What is it about?

Pemphigus vulgaris is a severe autoimmune disease diagnosed by painful erosions and extensive blistering of the skin and mucous membranes. Autoantibodies against epicutaneous antigens cause the blisters and erosions in pemphigus vulgaris. Among them, antigens such as desmoglein 1 and 3 are of particular importance. The aim of the author’s study was to determine the relationship between the levels of autoantibodies against desmoglein 1 and 3, using the enzyme-linked immunosorbent assay (ELISA) method in patients newly diagnosed with pemphigus vulgaris, and timeline of the disease among the patients hospitalized in Razi Hospital, Tehran, Iran, during 2013–2014.

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