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A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11C]methyl)benperidol
Sarah A. Eisenstein, Jo Ann V. Antenor-Dorsey, Danuta M. Gredysa, Jonathan M. Koller, Emily C. Bihun, Samantha A. Ranck, Ana Maria ArbelÁez, Samuel Klein, Joel S. Perlmutter, Stephen M. Moerlein, Kevin J. Black, Tamara Hershey
Synapse, May 2013, Wiley
Dr Kevin J. Black
Washington University in St. Louis
Several studies had compared "D2-like receptor availability" in obese vs. healthy-weight people. But this was the first study in people to measure D2 receptors specifically, using a method that is not affected by intrasynaptic dopamine concentrations at the time of the scan. The sample size was large enough to show that we could not have missed a big effect by chance.