A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11C]methyl)benperidol

Sarah A. Eisenstein, Jo Ann V. Antenor-Dorsey, Danuta M. Gredysa, Jonathan M. Koller, Emily C. Bihun, Samantha A. Ranck, Ana Maria ArbelÁez, Samuel Klein, Joel S. Perlmutter, Stephen M. Moerlein, Kevin J. Black, Tamara Hershey
  • Synapse, May 2013, Wiley
  • DOI: 10.1002/syn.21680

Perspectives

Dr Kevin J. Black
Washington University in St. Louis

Several studies had compared "D2-like receptor availability" in obese vs. healthy-weight people. But this was the first study in people to measure D2 receptors specifically, using a method that is not affected by intrasynaptic dopamine concentrations at the time of the scan. The sample size was large enough to show that we could not have missed a big effect by chance.

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http://dx.doi.org/10.1002/syn.21680

The following have contributed to this page: Dr Kevin J. Black