Reactive oxygen species impairs hematopoiesis.

What is it about?

Reactive oxygen species (ROS) quickly builds up in blood stem cells when they are cultured in vitro. We demonstrate that the ROS reducing factors specifically reduced ROS in more primitive hematopoietic fractions.

Featured Image

Why is it important?

We conclude that high levels of ROS in in vitro differentiation systems of hPSCs is a major determinant in the lack of ability to generate hematopoietic cells, and suggest that elevated ROS is a significant barrier to generating hPSC-derived repopulating HSCs.