What is it about?
We have engineered human embryonic stem cells with limit lifespan by inactivate the expression of telomerase. Such embryonic stem cells are still pluripotent. However, the teratoma formation incidence of telomerase-null embryonic stem cells is dramatically reduced in vivo. Similar strategy can be applied to iPS cells as well.
Featured Image
Why is it important?
Our studies provide a new strategy to dramatically improve the safety of stem cell therapy by inhibiting tumor formation.
Perspectives
Our new method can greatly improve the safety of stem cell therapy. With the genetic engineering tools that become widely available and accepted, we foresee the implementation of our technique in the clinic applications in the near future.
SHANG LI
Read the Original
This page is a summary of: Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy, Stem Cells, June 2016, Wiley,
DOI: 10.1002/stem.2431.
You can read the full text:
Contributors
The following have contributed to this page
