Nedd4 Regulates Pax7 Levels in Muscle Satellite Cells

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Why is it important?

Transcription factor Pax7 is a crucial regulator of adult muscle stem cell specification, maintenance and renewal. Little is known however about the mechanisms that control Pax7 function in order to orchestrate these processes. Here we show that Nedd4 regulates Pax7 protein levels through the ubiquitin proteasome system, directly affecting muscle stem cell fate.