What is it about?
In this work, we utilized a non-contact scanning probe microscope named scanning ion conductance microscopy to reveal the physical characteristics of base surfaces of genotype-defined metastatic intestinal organoids including local surface morphologies and stiffness in physiological condition.
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Why is it important?
The statistic stiffness analysis shows softness of base surface derived from eight types of organoids following a ranking: malignant tumor cells > benign tumor cells > normal cells. Moreover, the correlation factor between morphology and E is demonstrated depending on cell types. This work as first example reveals the subcellular morphologies and E distributions of base surface of cells.
Perspectives
The results would provide a clue for correlating genotype of 3D cells to malignant phenotype reflected by stiffness and offering a promising strategy for early-stage diagnosis of cancer.
Linhao Sun
Kanazawa Daigaku
Read the Original
This page is a summary of: Mapping Nanomechanical Properties of Basal Surfaces in Metastatic Intestinal 3D Living Organoids with High‐Speed Scanning Ion Conductance Microscopy, Small, December 2022, Wiley,
DOI: 10.1002/smll.202206213.
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